Laboratoire Bioinformatique

Application Domains

Methods

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  • Wheat regulation
  • Fonio
  • Classification of viruses
  • Reticulate evolution
  • Ancestral genomes and quasi species

An orphan disease is a pathology that does not have effective therapies, mainly due to the lack of prior knowledge and/or the scarcity of these diseases.

Indeed, most orphan diseases are rare diseases ; less than 1/2000 person is affected. According to the Regroupement Québécois des Maladies Orphelines (RQMO), this represents nearly 500,000 people in Quebec. There are more than 7,000 in the world, 80% of which are from genetic origin. Because they have long been little studied, rare diseases are difficult to treat, but also to diagnose.

  • Ancestral sequences reconstruction
  • Insertion and deletion in comparative genomes
  • Statistical Alignment
  • profile-profile Alignment
  • Stochastic model conception
  • Predictiction and characterization of microRNAs in the wheat genome under different stress condition
  • Understanding the molecular mechanisms involving miRNAs that regulate plant responses to abiotic stresses as well as the floral transition to flowering in hexaploid wheat
  • Functional classification of miRNAs based on the biological and physiological functions of their target genes
  • Computational prediction of microRNAs based on structural properties of the putative miRNA-miRNA* duplex
  • Genome annotation, genotyping and classification of Viruses
  • Identification of sets of patterns in the genome that correlate with the level of risk of the viruses
  • Mining Hierarchical Generalized Sequential Patterns
  • Ontologie enhancement in bioinformatics
  • Development of a platform for bioinformatic tasks automation with simplified acces to popular web ressources (Databases and programs)
  • Facilitate bioinformatics education
  • Worflow datamining in bioinformatics
  • Workflow refactoring